High colonization rate and prolonged shedding of Clostridium difficile in pediatric oncology patients.
نویسندگان
چکیده
Surveillance testing for Clostridium difficile among pediatric oncology patients identified stool colonization in 29% of patients without gastrointestinal symptoms and in 55% of patients with prior C. difficile infection (CDI). A high prevalence of C. difficile colonization and diarrhea complicates the diagnosis of CDI in this population.
منابع مشابه
Detection of Virulence Genes of Clostridium difficile in Children with Cancer by Multiplex PCR
Introduction: Toxigenic Clostridium difficile is the major cause of antibiotic-associated diarrhea, colitis, and pseudomembranous colitis. The pathogenicity of C. difficile is related to toxins A&B. Children with cancer are at risk of developing C. difficile infection (CDI) due to increased exposure to antibiotics, immunosuppression, and longer hospital stays. Recently, due to higher sensitivity...
متن کاملEFFECT OF AMYGDALUS COMMUNIS ON GROWTH AND TOXIN PRODUCTION OF CLOSTRIDIUM DIFFICILE
It is known that the major etiologic agent of pseudomembranous colitis in man is Clostridium difficile. With respect to traditional use of almond paste in the treatment of infantile diarrhea, we studied the effects of the aqueous extract of Amygdalus communis (AEAC) on the growth and toxin production of Clostridium difficile in culture medium and the rabbit ligated ileal loop. Three groups...
متن کاملEvaluation of bloodstream infections, Clostridium difficile infections, and gut microbiota in pediatric oncology patients
Bloodstream infections (BSI) and Clostridium difficile infections (CDI) in pediatric oncology/hematology/bone marrow transplant (BMT) populations are associated with significant morbidity and mortality. The objective of this study was to explore possible associations between altered microbiome composition and the occurrence of BSI and CDI in a cohort of pediatric oncology patients. Stool sample...
متن کاملDiagnostic and Therapeutic Considerations for Oncology Patients With Clostridium difficile Infection
Diagnosis and Classification Despite the impressive burden ofC difficile infection in the United States, it has become clear that there are many subtle complexities in diagnosis and classification of C difficile infection, which is also the case in oncology patients. Although toxigenic culture for C difficile is the gold-standard diagnostic technique, this method is infrequently performed becau...
متن کاملClostridium difficile Infection at Diagnosis and during the Disease Course of Pediatric Inflammatory Bowel Disease
Purpose Clostridium difficile colonization and infection are commonly associated with poor outcomes in patients with pediatric inflammatory bowel disease (PIBD). We aimed to investigate the prevalence of C. difficile colonization and infection at the time of diagnosis and to evaluate risk factors associated with the development of C. difficile infection during the course of PIBD treatment. Me...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
دوره 59 3 شماره
صفحات -
تاریخ انتشار 2014